Our Collies

 MDR1 (Multi-drug Resistance). MDR1 is a deletion gene which humans also have. It helps the body get rid of chemicals and toxins. When a dog has one or both Mutant genes, it may not be able to remove harmful chemicals through saliva, urine, feces and tears, effectively becoming poisoned as the chemicals pass the important barriers into the brain, stomach, and testes or other organs. Ivermectin is the most common wormer for animals but is dangerous to collies who have Mutant genes. Many breeders avoid Ivermectin regardless of the DNA scores of their herding dogs. The old veterinary adage "White feet, don't treat" applies. Collies tend to be sensitive to many commonly used chemicals/drugs. You will want to work closely with your vet, ensuring any medications they give are safe for collies. A collie with one or two Mutant genes is not less healthy or hearty: their score is valuable information on how to choose safe wormers, insecticides, and medications.